382175 | Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem

382175
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₃₀N₄O₆ 1045792-66-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      382175-1MG
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          1 mg
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          Description
          OverviewA cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50 <1.0 µM).
          Catalogue Number382175
          Brand Family Calbiochem®
          SynonymsHDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid
          References
          ReferencesKozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.
          Product Information
          CAS number1045792-66-2
          FormBeige to light brown solid
          Hill FormulaC₂₂H₃₀N₄O₆
          Chemical formulaC₂₂H₃₀N₄O₆
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          382175

          References

          Reference overview
          Kozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-November-2010 JSW
          SynonymsHDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid
          DescriptionA cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50 <1.0 µM).
          FormBeige to light brown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1045792-66-2
          Chemical formulaC₂₂H₃₀N₄O₆
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.