382120 Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem

382120
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₃ClF₃NO₂ 451491-47-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      382120-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
          Catalogue Number382120
          Brand Family Calbiochem®
          SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
          References
          ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
          Product Information
          CAS number451491-47-7
          FormOff-white solid
          Hill FormulaC₁₆H₁₃ClF₃NO₂
          Chemical formulaC₁₆H₁₃ClF₃NO₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          382120

          References

          Reference overview
          Mantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-September-2017 JSW
          SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
          DescriptionA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number451491-47-7
          Chemical formulaC₁₆H₁₃ClF₃NO₂
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityEthanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.