534034 Heterochromatin Inhibitor, HMS-I1 - Calbiochem

534034
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₁₄N₂O₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.34034.0001
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable imidazopyridine based compound that lacks canonical zinc chelating moieties and acts in a reversible manner to disrupt heterochromatin-mediated transcriptional gene silencing in mammalian, fungal, and plant cells (5 - 10 µM). Targets Clr3-containing Snf2/HDAC repressor complex (SHREC) and inhibits HDAC6 and HDAC10 activities. Increases G418 resistance of cen1-kanMX cells. Shown to diminish H3K9 methylation and increase H3K9 and H3K14 acetylation in cells grown in the presence of G418. Murine erythroleukemia (MEL) cells grown in the presence of this compound can overcome α-satellite repeats-mediated gene silencing.
          Catalogue Number534034
          Brand Family Calbiochem®
          Synonyms2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1
          DescriptionHeterochromatin Inhibitor, HMS-I1
          References
          ReferencesCastonguay, E., et al. 2015. Mol. Cell. Biol. 35, 662.
          Product Information
          FormPale yellow solid
          Hill FormulaC₁₆H₁₄N₂O₂
          Chemical formulaC₁₆H₁₄N₂O₂
          ReversibleY
          Applications
          Biological Information
          Primary TargetClr3-containing Snf2/HDAC repressor complex (SHREC)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Heterochromatin Inhibitor, HMS-I1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Castonguay, E., et al. 2015. Mol. Cell. Biol. 35, 662.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-June-2016 JSW
          Synonyms2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1
          DescriptionA cell-permeable imidazopyridine based compound that lacks canonical zinc chelating moieties and acts in a reversible manner to disrupt heterochromatin-mediated transcriptional gene silencing in mammalian, fungal, and plant cells (5 - 10 µM). Targets Clr3-containing Snf2/HDAC repressor complex (SHREC) and inhibits HDAC6 and HDAC10 activities. Increases G418 resistance of cen1-kanMX cells. Shown to diminish H3K9 methylation and increase H3K9 and H3K14 acetylation in cells grown in the presence of G418. Murine erythroleukemia (MEL) cells grown in the presence of this compound can overcome α-satellite repeats-mediated gene silencing.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₆H₁₄N₂O₂
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCastonguay, E., et al. 2015. Mol. Cell. Biol. 35, 662.