375680 Sigma-AldrichHesperadin - CAS 422513-13-1 - Calbiochem

Hesperadin primarily used in Inhibition.

Hesperadin - CAS 422513-13-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: Mammalian Ste20-like Kinase 4 Inhibitor, MST4 Inhibitor, Aurora Kinase Inhibitor X, AMPK Inhibitor II

Overview

Replacement Information

Key Specifications Table

Empirical Formula	CAS #
C₂₉H₃₂N₄O₃S	422513-13-1

Pricing & Availability

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375680-5MG	Retrieving availability... — Limited Availability Stocked Discontinued Limited Quantities Available Available Login to See Inventory Stocked Limited Availability Stocked Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Glass bottle	5 mg	Retrieving price... Price could not be retrieved Minimum Quantity needs to be mulitiple of Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites

Description
Overview	A cell-permeable indolinone compound that interacts with both the ATP- and the adjacent hydrophobic binding pocket of Aurora B and acts as a rapid and reversible inhibitor of Aurora kinase B activity (IC₅₀ ~ 250 nM) with moderate selectivity over Cdk1/B, Cdk2/E and Cdk4/D1 (IC₅₀ = 1.2, > 10 and > 10 µM). Also, potently inhibits several kinases at 1 µM in a 25-kinase screening panel (100%, 100%, 96%, 88%, 87% and 84% against Lck, PHK, AMPK, MKK1, MAPKAP-K1 and Chk1, respectively). Reported to reduce histone H3-Ser¹⁰ phosphorylation, inhibit cytokinesis, promote chromosome biorientation, perturb mitosis and polyploidy in mammalian cells. Recently shown to potently inhibit MST4 kinase (IC₅₀ = 6.18 nM) in an ATP-competitive manner. Dose-dependently accelerates hypoxia-induced apoptosis and decreases survival (EC₅₀ = 10 nM in MST4 LβT2 gonadotrope cells).
Catalogue Number	375680
Brand Family	Calbiochem®
Synonyms	Mammalian Ste20-like Kinase 4 Inhibitor, MST4 Inhibitor, Aurora Kinase Inhibitor X, AMPK Inhibitor II

References
References	Xiong, W., et al. 2016. Mol. Cancer Ther. 15, In press. Knowlton, A.L., et al. 2006. Curr. Biol. 16, 1705. Kapoor, T.M., et al. 2006. Science 311, 388. Hirota, T., et al. 2005. Nature 438, 1176. Sessa, F., et al. 2005. Mol. Cell. 18, 379. Lampson, M.A., et al. 2004. Nat. Cell Biol. 6, 232. Hauf, S., et al. 2003. J. Cell Biol. 161, 281.

Product Information
CAS number	422513-13-1
Form	Yellow solid
Hill Formula	C₂₉H₃₂N₄O₃S
Chemical formula	C₂₉H₃₂N₄O₃S
Structure formula Image

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Regulatory Review
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot freeze at -(20°C). Stock solutions are stable for up to 6 months at -20°C..

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Documentation

Hesperadin - CAS 422513-13-1 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

Hesperadin - CAS 422513-13-1 - Calbiochem Certificates of Analysis

Title	Lot Number
375680	Enter Lot Number

References

Reference overview
Xiong, W., et al. 2016. Mol. Cancer Ther. 15, In press. Knowlton, A.L., et al. 2006. Curr. Biol. 16, 1705. Kapoor, T.M., et al. 2006. Science 311, 388. Hirota, T., et al. 2005. Nature 438, 1176. Sessa, F., et al. 2005. Mol. Cell. 18, 379. Lampson, M.A., et al. 2004. Nat. Cell Biol. 6, 232. Hauf, S., et al. 2003. J. Cell Biol. 161, 281.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-August-2011 RFH
Synonyms	Mammalian Ste20-like Kinase 4 Inhibitor, MST4 Inhibitor, Aurora Kinase Inhibitor X, AMPK Inhibitor II
Description	A cell-permeable indolinone compound that interacts with both the ATP- and the adjacent hydrophobic binding pocket of Aurora B and acts as a rapid and reversible inhibitor of Aurora kinase B activity (IC₅₀ ~250 nM) with moderate selectivity over Cdk1/B, Cdk2/E and Cdk4/D1 (IC₅₀ = 1.2, > 10 and > 10 µM). Also, potently inhibits several kinases at 1 µM in a 25-kinase screening panel (100%, 100%, 96%, 88%, 87% and 84% against Lck, PHK, AMPK, MKK1, MAPKAP-K1 and Chk1, respectively). Reported to reduce histone H3-Ser¹⁰ phosphorylation, inhibit cytokinesis, promote chromosome biorientation, perturb mitosis and polyploidy in mammalian cells.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	422513-13-1
Chemical formula	C₂₉H₃₂N₄O₃S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	-20°C Protect from light
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot freeze at -(20°C). Stock solutions are stable for up to 6 months at -20°C..
Toxicity	Regulatory Review
References	Xiong, W., et al. 2016. Mol. Cancer Ther. 15, In press. Knowlton, A.L., et al. 2006. Curr. Biol. 16, 1705. Kapoor, T.M., et al. 2006. Science 311, 388. Hirota, T., et al. 2005. Nature 438, 1176. Sessa, F., et al. 2005. Mol. Cell. 18, 379. Lampson, M.A., et al. 2004. Nat. Cell Biol. 6, 232. Hauf, S., et al. 2003. J. Cell Biol. 161, 281.