373225 | Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

373225
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₈F₆N₂O₃S 414905-09-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      373225-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 > 100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
          Catalogue Number373225
          Brand Family Calbiochem®
          SynonymsN-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, MDM2 Inhibitor V, Mdm2 E3 Ligase Inhibitor
          References
          ReferencesLai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.
          Product Information
          CAS number414905-09-2
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₁₀H₈F₆N₂O₃S
          Chemical formulaC₁₀H₈F₆N₂O₃S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetubiquitination of p53 in vitro
          Primary Target IC<sub>50</sub>12.7 µM inhibiting ubiquitination of p53 in vitro using Ub-Ubc as the donor substrate
          Purity≥95% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          373225

          References

          Reference overview
          Lai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-July-2014 JSW
          SynonymsN-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, MDM2 Inhibitor V, Mdm2 E3 Ligase Inhibitor
          DescriptionA cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 >100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number414905-09-2
          Chemical formulaC₁₀H₈F₆N₂O₃S
          Structure formulaStructure formula
          Purity≥95% by NMR
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.