531470 HIV TAR Hairpin Binder - Calbiochem

531470
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₁₂F₃N₃OS

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31470.0001
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable, non-cytotoxic, non cationic thienopyridine compound that potently and dose-dependently inhibits HIV-mediated cytopathicity (EC50 = 28 µM in T lymphocytes) and displays antiviral properties. Shown to specifically bind and stabilize HIV transactivation response (TAR) element RNA hairpin motif (Kd = 2.4 µM) in a reversible manner without disrupting 5′ untranslated region (UTR).

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531470
          Brand Family Calbiochem®
          Synonyms3-Amino-6-methyl-N-(3-(trifluoromethyl)phenyl)thieno[2,3-b]pyridine-2-carboxamide, (3-Amino-6-methylthiopheno[2,3-b]pyridin-2-yl)-N-(3-(trifluoromethyl)phenyl)carboxamide, HIV TAR Hairpin Stabilizer
          References
          ReferencesSztuba-Solinska, J., et al. 2014. J. Am. Chem. Soc. 136, 8402.
          Product Information
          FormYellow powder
          Hill FormulaC₁₆H₁₂F₃N₃OS
          Chemical formulaC₁₆H₁₂F₃N₃OS
          ReversibleY
          Applications
          Biological Information
          Primary TargetHIV transactivation response (TAR) element RNA
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          HIV TAR Hairpin Binder - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Sztuba-Solinska, J., et al. 2014. J. Am. Chem. Soc. 136, 8402.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-August-2014 JSW
          Synonyms3-Amino-6-methyl-N-(3-(trifluoromethyl)phenyl)thieno[2,3-b]pyridine-2-carboxamide, (3-Amino-6-methylthiopheno[2,3-b]pyridin-2-yl)-N-(3-(trifluoromethyl)phenyl)carboxamide, HIV TAR Hairpin Stabilizer
          DescriptionA cell-permeable, non-cationic thienopyridine compound that selectively targets HIV-1 transactivation response (TAR) hairpin motif (Kd = 2.4 µM), but not other structural elements in HIV-1 5′ untranslated region (UTR), via hydrophobic & aromatic type of interactions, reducing TAR conformational flexibility without affecting UTR dimerization. Shown to protect T-lymphoblastoid cell line CEM-SS against HIV-1-induced cytopathicity (% cell survival/[drug] in µM = 90%/550, 78%/167, 50%/28 in 6-d infected cultures by XTT) without conferring cytotoxicity in non-infected cultures even at concentrations as high as 550 µM.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₆H₁₂F₃N₃OS
          Purity≥97% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSztuba-Solinska, J., et al. 2014. J. Am. Chem. Soc. 136, 8402.