400087 HIF-2α Translation Inhibitor - CAS 882268-69-1 - Calbiochem

400087
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₉N₃O₄S₂ 882268-69-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      400087-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5 to 10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
          Catalogue Number400087
          Brand Family Calbiochem®
          SynonymsHypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
          References
          ReferencesZimmer, M., et al. 2008. Mol. Cell 32, 838.
          Product Information
          CAS number882268-69-1
          FormAmber solid
          Hill FormulaC₉H₉N₃O₄S₂
          Chemical formulaC₉H₉N₃O₄S₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% (sum of two isomers)
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          400087

          References

          Reference overview
          Zimmer, M., et al. 2008. Mol. Cell 32, 838.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsHypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
          DescriptionA cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5-10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
          FormAmber solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number882268-69-1
          Chemical formulaC₉H₉N₃O₄S₂
          Structure formulaStructure formula
          Purity≥95% (sum of two isomers)
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesZimmer, M., et al. 2008. Mol. Cell 32, 838.