371958 H-8, Dihydrochloride

371958
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₁₅N₃O₂S · 2HCl 113276-94-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      371958-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits protein kinase A (Ki = 1.2 µM), myosin light chain kinase (Ki = 68 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).
          Catalogue Number371958
          Brand Family Calbiochem®
          SynonymsN-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I
          References
          ReferencesIdo, M., et al. 1991. Br. J. Cancer 64, 1103.
          Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
          Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
          Hidaka, H., et al. 1984. Biochemistry 23, 5036.
          Product Information
          CAS number113276-94-1
          ATP CompetitiveY
          FormLyophilized
          Hill FormulaC₁₂H₁₅N₃O₂S · 2HCl
          Chemical formulaC₁₂H₁₅N₃O₂S · 2HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMLCK
          Primary Target K<sub>i</sub>68 µM against MLCK
          Purity>95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          371958

          References

          Reference overview
          Ido, M., et al. 1991. Br. J. Cancer 64, 1103.
          Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
          Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
          Hidaka, H., et al. 1984. Biochemistry 23, 5036.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-January-2010 RFH
          SynonymsN-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I
          DescriptionA potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (Ki = 68 µM), protein kinase A (Ki = 1.2 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).
          FormLyophilized
          CAS number113276-94-1
          Chemical formulaC₁₂H₁₅N₃O₂S · 2HCl
          Structure formulaStructure formula
          Purity>95% by TLC
          SolubilityH₂O (10 mg/ml). Further dilute with aqueous buffer just prior to use.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
          Toxicity Standard Handling
          ReferencesIdo, M., et al. 1991. Br. J. Cancer 64, 1103.
          Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
          Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
          Hidaka, H., et al. 1984. Biochemistry 23, 5036.