370665 | Guanosine-3ʹ-5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Triethylammonium Salt - Calbiochem

370665
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      370665-25UMOL
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          Plastic ampoule 25 umol
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          Description
          OverviewSelective membrane-permeable activator of protein kinase G that has a higher activation potential than cGMP. Does not significantly affect cGMP-regulated phosphodiesterases. Inhibits the thrombin-induced phosphorylation of human platelets mediated by myosin light chain kinase (MLCK) and protein kinase C (PKC). Note: 25 µmol = 14.73 mg.
          Catalogue Number370665
          Brand Family Calbiochem®
          Synonyms8-pCPT-cGMP, TEA
          References
          ReferencesAlioua, A., et al. 1998. J. Biol. Chem. 273, 32950.
          Draijer, R., et al. 1995. Circ. Res. 77, 895.
          Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 1031.
          Wolfe, L., et al. 1989. J. Biol. Chem. 264, 7734.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          Hill FormulaC₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
          Chemical formulaC₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetProtein kinase G
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          370665

          References

          Reference overview
          Alioua, A., et al. 1998. J. Biol. Chem. 273, 32950.
          Draijer, R., et al. 1995. Circ. Res. 77, 895.
          Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 1031.
          Wolfe, L., et al. 1989. J. Biol. Chem. 264, 7734.

          Brochure

          Title
          Nucleotides and Bases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-July-2008 RFH
          Synonyms8-pCPT-cGMP, TEA
          DescriptionSelective membrane-permeable activator of protein kinase G. Has a higher activation potential than cGMP. Does not significantly affect cGMP-regulated phosphodiesterases. Inhibits the thrombin-induced phosphorylation of human platelets mediated by myosin light chain kinase (MLCK) and protein kinase C (PKC). Note: 25 µmol = 14.73 mg
          FormLyophilized
          Chemical formulaC₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAlioua, A., et al. 1998. J. Biol. Chem. 273, 32950.
          Draijer, R., et al. 1995. Circ. Res. 77, 895.
          Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 1031.
          Wolfe, L., et al. 1989. J. Biol. Chem. 264, 7734.