368055 Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem

368055
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₃₄N₄O₁₀ 1258003-96-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      368055-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).
          Catalogue Number368055
          Brand Family Calbiochem®
          SynonymsCaspase-8 Inhibitor I, Ac-IETD-CHO
          References
          ReferencesGao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.
          Product Information
          CAS number1258003-96-1
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₂₁H₃₄N₄O₁₀
          Chemical formulaC₂₁H₃₄N₄O₁₀
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcaspase-8
          Primary Target K<sub>i</sub>1 nM against caspase-8
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceAc-Ile-Glu-Thr-Asp-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          368055

          References

          Reference overview
          Gao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2011 RFH
          SynonymsCaspase-8 Inhibitor I, Ac-IETD-CHO
          DescriptionPotent, reversible granzyme B and caspase-8 inhibitor.
          FormWhite lyophilized solid
          CAS number1258003-96-1
          Chemical formulaC₂₁H₃₄N₄O₁₀
          Peptide SequenceAc-Ile-Glu-Thr-Asp-CHO
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesGao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

          Related Products & Applications

          Alternative Products

          Catalog Number Description  
          368050 Granzyme B Inhibitor I - Calbiochem Show Pricing & Availability

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Granzyme Inhibitors