368020 Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem

368020
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉₉H₁₄₀N₂₀O₁₇ 11029-61-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      368020-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewNaturally-occurring ion channel-forming pentadecapeptide. The association of two gA peptides causes the formation of a monovalent cation-selective ion channel. Causes K+/H+ exchange in mitochondria in a non-voltage dependent manner. Causes red blood cell lysis at 0.5-1.0 µg/ml.
          Catalogue Number368020
          Brand Family Calbiochem®
          SynonymsgA
          References
          ReferencesQuigley, E.P., et al. 2000. J. Membr. Biol. 174, 207.
          Koeppe, R.E., et al. 1995. Biochemistry 34, 9299.
          Ketchem, R.R., et al. 1993. Science 261, 1457.
          Stankovic, C.J., et al. 1990. Anal. Biochem. 184, 100.
          Product Information
          CAS number11029-61-1
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₉₉H₁₄₀N₂₀O₁₇
          Chemical formulaC₉₉H₁₄₀N₂₀O₁₇
          ReversibleN
          Applications
          Biological Information
          Primary TargetCauses the formation of a monovalent cation-selective ion channel
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          ContaminantsgC isomers: < 5% by HPLC
          Peptide SequenceHCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH₂CH₂OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMD8230000
          Safety Information
          R PhraseR: 20/21/22-36/37/38

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing recosntituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          368020

          References

          Reference overview
          Quigley, E.P., et al. 2000. J. Membr. Biol. 174, 207.
          Koeppe, R.E., et al. 1995. Biochemistry 34, 9299.
          Ketchem, R.R., et al. 1993. Science 261, 1457.
          Stankovic, C.J., et al. 1990. Anal. Biochem. 184, 100.

          Brochure

          Title
          Ionophores Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-March-2012 JSW
          SynonymsgA
          DescriptionNaturally occurring, ion channel-forming pentadecapeptide antibiotic that renders membranes permeable to protons and alkali metal ions. Causes red blood cell lysis at concentrations of 0.5-1.0 µg/ml. Gramicidin A causes K+/H+ exchange in mitochondria in a non-voltage dependent manner.
          FormWhite to off-white solid
          CAS number11029-61-1
          RTECSMD8230000
          Chemical formulaC₉₉H₁₄₀N₂₀O₁₇
          Peptide SequenceHCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH₂CH₂OH
          Purity≥90% by HPLC
          ContaminantsgC isomers: < 5% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing recosntituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 4532
          ReferencesQuigley, E.P., et al. 2000. J. Membr. Biol. 174, 207.
          Koeppe, R.E., et al. 1995. Biochemistry 34, 9299.
          Ketchem, R.R., et al. 1993. Science 261, 1457.
          Stankovic, C.J., et al. 1990. Anal. Biochem. 184, 100.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores