356310 | Glyburide - CAS 10238-21-8 - Calbiochem

356310
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₂₈ClN₃O₅S 10238-21-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      356310-1GM
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 1 gm
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. Inhibits the vasorelaxing effects of nitric oxide.
          Catalogue Number356310
          Brand Family Calbiochem®
          SynonymsGlybenclamide
          References
          ReferencesHolzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
          Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
          Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
          Jacobs, D.R., et al. 1989. Diabetes 38, 205.
          Product Information
          CAS number10238-21-8
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₃H₂₈ClN₃O₅S
          Chemical formulaC₂₃H₂₈ClN₃O₅S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetATP-sensitive K+ channels
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYS4725200
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          356310

          References

          Reference overview
          Holzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
          Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
          Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
          Jacobs, D.R., et al. 1989. Diabetes 38, 205.

          Brochure

          Title
          Channel Blockers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-May-2008 RFH
          SynonymsGlybenclamide
          DescriptionAntidiabetic sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. High-affinity binding sites are widely distributed and have been identified in the cardiovascular system, the central nervous system, and pancreatic β-cells. In cultured cells, glyburide enhances insulin action and stimulates the synthesis of glucose transporters. Displays large potency difference in action on pancreatic tissue (IC50 in nM range) and vascular tissue (IC50 in µM range).
          FormWhite solid
          CAS number10238-21-8
          RTECSYS4725200
          Chemical formulaC₂₃H₂₈ClN₃O₅S
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (25 mg/ml) or Ethanol (5 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 4478
          ReferencesHolzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
          Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
          Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
          Jacobs, D.R., et al. 1989. Diabetes 38, 205.