345733 | Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

345733
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₆₄H₁₁₈N₂O₂₁ · NH₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345733-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewContains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC50 = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
          M.W. 1198.5 (based on stearoyl - 18:0).
          Catalogue Number345733
          Brand Family Calbiochem®
          SynonymsNeu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
          References
          ReferencesKatoh, N. 1995. Life Sci. 56, 157.
          Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
          Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
          Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₆₄H₁₁₈N₂O₂₁ · NH₄
          Chemical formulaC₆₄H₁₁₈N₂O₂₁ · NH₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetProtein kinase C, EGF-receptor tyrosine kinase
          Primary Target IC<sub>50</sub>100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345733

          References

          Reference overview
          Katoh, N. 1995. Life Sci. 56, 157.
          Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
          Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
          Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.

          Brochure

          Title
          Gangliosides Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-September-2007 RFH
          SynonymsNeu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
          DescriptionContains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in the biosynthesis and metabolism of higher gangliosides. Inhibits protein kinase C activity in both cytosolic and total particulate fractions(IC50 = 100-115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
          FormWhite solid
          Chemical formulaC₆₄H₁₁₈N₂O₂₁ · NH₄
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityChloroform:Methanol (2:1)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesKatoh, N. 1995. Life Sci. 56, 157.
          Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
          Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
          Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.