505296 | GYKI 53655 Hydrochloride - CAS 143692-48-2 - Calbiochem

505296
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₀N₄O₃•HCl 143692-48-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05296.0001
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          Glass bottle 10 mg
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          Description
          OverviewA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 6 and 5 µM for GluA1 and GluA4, respectively) over kainate receptors (IC50 = 63 and 32 µM for GluK3 and GluK2b/GluK3 receptors. Used as neuroprotectant and anticonvulsant, and a valuable tool for the study of AMPA receptor-mediated processes in vivo.
          Catalogue Number505296
          Brand Family Calbiochem®
          SynonymsLY 300168, GYKI-53655 hydrochloride, AMPA Glutamate Receptor Antagonist, GYKI 53655 hydrochloride, 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
          References
          ReferencesKromann, H. et al. 2002. J. Med. Chem. 45, 5745.
          Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
          Lante, F., et al. 2011. J. Neurosci. 31, 3953.
          Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
          Jackson, C., et al. 2011. J. Neurosci. 31, 7511.
          Product Information
          CAS number143692-48-2
          FormOrange solid
          Hill FormulaC₁₉H₂₀N₄O₃•HCl
          Chemical formulaC₁₉H₂₀N₄O₃•HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAMPA
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Kromann, H. et al. 2002. J. Med. Chem. 45, 5745.
          Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
          Lante, F., et al. 2011. J. Neurosci. 31, 3953.
          Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
          Jackson, C., et al. 2011. J. Neurosci. 31, 7511.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          SynonymsLY 300168, GYKI-53655 hydrochloride, AMPA Glutamate Receptor Antagonist, GYKI 53655 hydrochloride, 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
          DescriptionA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 6 and 5 µM for GluA1 and GluA4, respectively) over kainate receptors (IC50 = 63 and 32 µM for GluK3 and GluK2b/GluK3 receptors. Used as neuroprotectant and anticonvulsant, and a valuable tool for the study of AMPA receptor-mediated processes in vivo.
          FormOrange solid
          CAS number143692-48-2
          Chemical formulaC₁₉H₂₀N₄O₃•HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKromann, H. et al. 2002. J. Med. Chem. 45, 5745.
          Nilsen, A., et al. 2007. J. Am. Chem. Soc. 129, 4902.
          Lante, F., et al. 2011. J. Neurosci. 31, 3953.
          Argilli, E., et al. 2008. J. Neurosci. 28, 9092.
          Jackson, C., et al. 2011. J. Neurosci. 31, 7511.