504973 | GYKI 52466 Hydrochloride - CAS 102771-26-6 - Calbiochem

504973
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₅N₃O₂•HCl 102771-26-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04973.0001
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 10-20 µM) over kainate (IC50 ~ 450 µM) and NMDA (IC50 >> 50 µM) receptors. Commonly used as neuroprotectant, anticonvulsant, and skeletal muscle relaxant. Biologically viable admitted orally or systematically.
          Catalogue Number504973
          Brand Family Calbiochem®
          Synonyms1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine Hydrochloride, GYKI-52,466, GYK I52466
          References
          ReferencesNayak, P., et al. 2013. Neuroscience. 232, 139.
          Goulton, C., et al. 2010. Front. Neurosci. 4, 54.
          Arai, C., 2001. Brain Res. 892, 396.
          Wilding, J., et al. 1995. Mol. Pharmacol. 47, 582.
          Donevan, D., et al. 1993. Neuron 10, 51.
          Product Information
          CAS number102771-26-6
          FormYellow solid
          Hill FormulaC₁₇H₁₅N₃O₂•HCl
          Chemical formulaC₁₇H₁₅N₃O₂•HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAMPA
          Primary Target IC<sub>50</sub>10 – 20 →M
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Nayak, P., et al. 2013. Neuroscience. 232, 139.
          Goulton, C., et al. 2010. Front. Neurosci. 4, 54.
          Arai, C., 2001. Brain Res. 892, 396.
          Wilding, J., et al. 1995. Mol. Pharmacol. 47, 582.
          Donevan, D., et al. 1993. Neuron 10, 51.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          Synonyms1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine Hydrochloride, GYKI-52,466, GYK I52466
          DescriptionA potent negative allosteric modulator selective for AMPA glutamate receptors (IC50 = 10-20 µM) over kainate (IC50 ~ 450 µM) and NMDA (IC50 >> 50 µM) receptors. Commonly used as neuroprotectant, anticonvulsant, and skeletal muscle relaxant. Biologically viable admitted orally or systematically.
          FormYellow solid
          CAS number102771-26-6
          Chemical formulaC₁₇H₁₅N₃O₂•HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesNayak, P., et al. 2013. Neuroscience. 232, 139.
          Goulton, C., et al. 2010. Front. Neurosci. 4, 54.
          Arai, C., 2001. Brain Res. 892, 396.
          Wilding, J., et al. 1995. Mol. Pharmacol. 47, 582.
          Donevan, D., et al. 1993. Neuron 10, 51.