370700 GW9662 - CAS 22978-25-2 - Calbiochem

370700
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₉ClN₂O₃ 22978-25-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      370700-5MG
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          Plastic ampoule 5 mg
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          Description
          Overview

          This product has been discontinued.



          A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-α (LXRα), retinoic acid receptor (RAR), retinoid X receptor-α (RXRα) and thyroid receptors α and β (TRα and TRβ).

          Catalogue Number370700
          Brand Family Calbiochem®
          Synonyms2-Chloro-5-nitro-N-phenylbenzamide
          References
          ReferencesLeesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
          Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
          Huang, J.T., et al. 1999. Nature 400, 378.
          Product Information
          CAS number22978-25-2
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₁₃H₉ClN₂O₃
          Chemical formulaC₁₃H₉ClN₂O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPPARγ
          Primary Target IC<sub>50</sub>3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          370700

          References

          Reference overview
          Leesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
          Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
          Huang, J.T., et al. 1999. Nature 400, 378.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2016 JSW
          Synonyms2-Chloro-5-nitro-N-phenylbenzamide
          DescriptionA cell-permeable, selective, and irreversible PPAPγ antagonist (IC50 = 3.3 nM, 32 nM, and 2.0 µM for PPARγ, PPARα, and PPARδ, respectively) that is reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor α (LXRα), retinoic acid receptor (RAR), retinoid X receptor α (RXRα), or thyroid receptors α and β (TRα and TRβ).
          FormCrystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number22978-25-2
          Chemical formulaC₁₃H₉ClN₂O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml) or Methanol
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLeesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
          Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
          Huang, J.T., et al. 1999. Nature 400, 378.