370698 GW7647 - CAS 265129-71-3 - Calbiochem

370698
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₄₆N₂O₃S 265129-71-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      370698-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARα agonist (PPARα, γ and δ - EC50 = 6 nM, 1.1 µM and 6.2 µM for human; 1 nM, 1.3 µM and 2.9 µM for murine, respectively). Also displays in vivo lipid-lowering activity in rats.
          Catalogue Number370698
          Brand Family Calbiochem®
          SynonymsGW647, 2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid, PPAR Agonist IV, PPARα Agonist II, PPARβ/δ Agonist I, PPARγ Agonist III
          References
          ReferencesMuoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089.
          Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225.
          Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306.
          Poirier, H., et al. 2001. Biochem. J. 355, 481.
          Product Information
          CAS number265129-71-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₉H₄₆N₂O₃S
          Chemical formulaC₂₉H₄₆N₂O₃S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPPARα
          Primary Target IC<sub>50</sub>EC50 = 6 nM, 1.1 µM and 6.2 µM for human PPARα, γ and δ, respectively; EC50 = 1 nM, 1.3 µM and 2.9 µM for murine PPARα, γ and δ, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          370698

          References

          Reference overview
          Muoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089.
          Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225.
          Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306.
          Poirier, H., et al. 2001. Biochem. J. 355, 481.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-July-2008 RFH
          SynonymsGW647, 2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid, PPAR Agonist IV, PPARα Agonist II, PPARβ/δ Agonist I, PPARγ Agonist III
          DescriptionA cell-permeable, urea-substituted, thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 6 nM for human PPARα, 1.1 µM for human PPARγ, and 6.2 µM human PPARδ; 1 nM for murine PPARα, 1.3 µM for murine PPARγ, and 2.9 µM murine PPARδ). Also shown to lower lipid levels in rats.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number265129-71-3
          Chemical formulaC₂₉H₄₆N₂O₃S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml) or Ethanol (12 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesMuoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089.
          Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225.
          Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306.
          Poirier, H., et al. 2001. Biochem. J. 355, 481.