361553 GSK-3β Inhibitor XI - CAS 626604-39-5 - Calbiochem

361553
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₅N₅O₃ 626604-39-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      361553-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable azaindolylmaleimide compound that acts as a potent, specific, and ATP-competitive inhibitor of GSK-3β (Ki = 25 nM) and minimally inhibits a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells with an EC50 of 32 nM and demonstrate metabolic stability in human liver microsomes (HLM; t1/2 > 100 min).
          Catalogue Number361553
          Brand Family Calbiochem®
          Synonyms3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM
          References
          ReferencesJustman, Q.A., et al. 2009. Science 324, 509.
          O'Neill, D.J., et al. 2004. Bioorg. Med. Chem. 12, 3167.
          Product Information
          CAS number626604-39-5
          ATP CompetitiveY
          FormOrange red solid
          Hill FormulaC₁₈H₁₅N₅O₃
          Chemical formulaC₁₈H₁₅N₅O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGsk-3β
          Primary Target K<sub>i</sub>25 nM against GSK-3β
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          361553

          References

          Reference overview
          Justman, Q.A., et al. 2009. Science 324, 509.
          O'Neill, D.J., et al. 2004. Bioorg. Med. Chem. 12, 3167.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2009 RFH
          Synonyms3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM
          DescriptionA cell-permeable, potent, specific, and ATP-competitive inhibitor of GSK-3β (Ki = 25 nM) that exhibits minimal inhibition against a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells (EC50 = 32 nM) and demonstrate metabolic stability in human liver microsomes (HLM; t1/2 >100 min).
          FormOrange red solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number626604-39-5
          Chemical formulaC₁₈H₁₅N₅O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesJustman, Q.A., et al. 2009. Science 324, 509.
          O'Neill, D.J., et al. 2004. Bioorg. Med. Chem. 12, 3167.