361551 GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem

361551
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₂BrN₃O₃ 740841-15-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      361551-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewAn acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 ≥ 10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50 = 0.16 µM) reporter systems.
          Catalogue Number361551
          Brand Family Calbiochem®
          Synonyms(2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime
          References
          ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Product Information
          CAS number740841-15-0
          ATP CompetitiveN
          FormDark purple solid
          Hill FormulaC₁₈H₁₂BrN₃O₃
          Chemical formulaC₁₈H₁₂BrN₃O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGSK-3α/β
          Primary Target IC<sub>50</sub>10 nM against GSK-3α/β
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          361551

          References

          Reference overview
          Knockaert, M., et al. 2004. Oncogene 23, 4400.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          Synonyms(2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime
          DescriptionAn acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 µM, 4.3 µM, and 63 µM, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 ≥ 10 µM). Yields BIO (Cat. No. 361550) upon hydrolysis.
          FormDark purple solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number740841-15-0
          Chemical formulaC₁₈H₁₂BrN₃O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml). Limited solubility in aqueous buffers; serial dilutions in DMSO may be required prior to dilution in buffer.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.