361556 | GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem

361556
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₂BrN₃O₂ 710323-61-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      361556-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 > 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
          Catalogue Number361556
          Brand Family Calbiochem®
          Synonyms1-Methyl-BIO
          References
          ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Product Information
          CAS number710323-61-8
          ATP CompetitiveN
          FormDark red solid
          Hill FormulaC₁₇H₁₂BrN₃O₂
          Chemical formulaC₁₇H₁₂BrN₃O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetRelevant kinase inactive control
          Primary Target IC<sub>50</sub>> 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          361556

          References

          Reference overview
          Knockaert, M., et al. 2004. Oncogene 23, 4400.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          Synonyms1-Methyl-BIO
          DescriptionA cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC50 >92 µM for Cdk1/cyclin B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
          FormDark red solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number710323-61-8
          Chemical formulaC₁₇H₁₂BrN₃O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors