361550 | GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

361550
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₀BrN₃O₂ 667463-62-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      361550-10MG
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          Plastic ampoule 10 mg
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          361550-1MG
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              Plastic ampoule 1 mg
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              361550-30MG
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                  Description
                  OverviewA cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available.
                  Catalogue Number361550
                  Brand Family Calbiochem®
                  SynonymsBIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
                  References
                  ReferencesTseng, A-S., et al. 2006. Chem. Biol. 13, 957.
                  Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
                  Sato, N., et al. 2004. Nat. Med. 10, 55.
                  Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
                  Product Information
                  CAS number667463-62-9
                  ATP CompetitiveY
                  FormPurple solid
                  Hill FormulaC₁₆H₁₀BrN₃O₂
                  Chemical formulaC₁₆H₁₀BrN₃O₂
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Primary TargetGSK-3α/β
                  Primary Target IC<sub>50</sub>5 nM against GSK-3α/β
                  Purity≥97% by HPLC
                  Physicochemical Information
                  Cell permeableY
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  R PhraseR: 20/21/22

                  Harmful by inhalation, in contact with skin and if swallowed.
                  S PhraseS: 22-36/37

                  Do not breathe dust.
                  Wear suitable protective clothing and gloves.
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Shipped with Blue Ice or with Dry Ice
                  Toxicity Carcinogenic / Teratogenic
                  Storage +2°C to +8°C
                  Protect from Light Protect from light
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Packaging Information
                  Packaged under inert gas Packaged under inert gas
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  361550

                  References

                  Reference overview
                  Tseng, A-S., et al. 2006. Chem. Biol. 13, 957.
                  Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
                  Sato, N., et al. 2004. Nat. Med. 10, 55.
                  Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

                  Citations

                  Title
                • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision03-April-2008 RFH
                  SynonymsBIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
                  DescriptionA cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk's (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes.
                  FormPurple solid
                  Intert gas (Yes/No) Packaged under inert gas
                  CAS number667463-62-9
                  Chemical formulaC₁₆H₁₀BrN₃O₂
                  Structure formulaStructure formula
                  Purity≥97% by HPLC
                  SolubilityDMSO (5 mg/ml)
                  Storage +2°C to +8°C
                  Protect from light
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
                  Toxicity Carcinogenic / Teratogenic
                  ReferencesTseng, A-S., et al. 2006. Chem. Biol. 13, 957.
                  Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
                  Sato, N., et al. 2004. Nat. Med. 10, 55.
                  Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
                  Citation
                • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
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                  Categories

                  Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors