371758 | GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem

371758
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      Overview

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      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      371758-100MG
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          Glass bottle 100 mg
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          Description
          OverviewA hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~ 7, 16, 17, 22, and 67 µM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR. Orally active in mice and exhibits NEFAc cholesterol-lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100 mg/kg, p.o.) in vivo.
          Catalogue Number371758
          Brand Family Calbiochem®
          Synonyms3-Chloro-5-hydroxybenzoic acid, Hydroxycarboxylic Acid Receptor 1 Agonist
          References
          ReferencesDvorak, C.A., et al. 2012. ACS Med. Chem. Lett. 3, 637.
          Product Information
          CAS number53984-36-4
          FormLight beige solid
          Hill FormulaC₇H₅ClO₃
          Chemical formulaC₇H₅ClO₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGPR81
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          371758

          References

          Reference overview
          Dvorak, C.A., et al. 2012. ACS Med. Chem. Lett. 3, 637.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-May-2013 JSW
          Synonyms3-Chloro-5-hydroxybenzoic acid, Hydroxycarboxylic Acid Receptor 1 Agonist
          DescriptionA hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~ 7, 16, 17, 22, and 67 µM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR (EC50 >1 mM). Displays good pharmacokinetic characteristics in mice (Cmax/t1/2 = 67.2 µM/1.47 h and 341.9 µM/1.1 h, respectively, upon oral dosing at 30 mg/kg and 100 mg/kg) and exhibits NEFAc- (non-esterified free fatty acid cholesterol) lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100 mg/kg, p.o.) in vivo.
          FormLight beige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number53984-36-4
          Chemical formulaC₇H₅ClO₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesDvorak, C.A., et al. 2012. ACS Med. Chem. Lett. 3, 637.