371822 GPR120 Agonist III - Calbiochem

371822
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      371822-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA membrane-permeant biphenyl-methoxy-phenylpropanoate compound that acts as an active-site targeting, selective, potent agonist of G-protein coupled receptor 120/GPR120 (EC50 of β-arrestin 2 recruitment = 17 nM and 44 nM for mGPR120 and hGPR120, respectively; EC50 of Ca++ mobilization = 96 nM for hGPR120). Exhibits much reduced potency toward free fatty acid receptor 1/FFA1/GPR40 (EC50 of β-arrestin 2 recruitment = 64.6 µM) and no activity toward short chain FFA receptors FFA2/GPR43 and FFA3/GPR41.
          Catalogue Number371822
          Brand Family Calbiochem®
          Synonyms3-(4-((4-Fluoro-4ʹ-methyl-(1,1ʹ-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid
          References
          ReferencesShimpukade, B., et al. 2012. J. Med. Chem. 55, 4511.
          Product Information
          FormWhite powder
          Hill FormulaC₂₃H₂₁FO₃
          ReversibleY
          Applications
          Biological Information
          Primary TargetG-protein coupled receptor 120
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          371822

          References

          Reference overview
          Shimpukade, B., et al. 2012. J. Med. Chem. 55, 4511.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-October-2012 JSW
          Synonyms3-(4-((4-Fluoro-4ʹ-methyl-(1,1ʹ-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid
          DescriptionA membrane-permeant biphenyl-methoxy-phenylpropanoate compound that acts as an active-site targeting, selective, potent agonist of G-protein coupled receptor 120/GPR120 (EC50 of β-arrestin 2 recruitment = 17 nM and 44 nM for mGPR120 and hGPR120, respectively; EC50 of Ca++ mobilization = 96 nM for hGPR120). Exhibits much reduced potency toward free fatty acid receptor 1/FFA1/GPR40 (EC50 of β-arrestin 2 recruitment = 64.6 µM) and no activity toward short chain FFA receptors FFA2/GPR43 and FFA3/GPR41.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesShimpukade, B., et al. 2012. J. Med. Chem. 55, 4511.