538254 GN44028 - Calbiochem

538254
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      Overview

      Replacement Information

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      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.38254.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable indenopyrazole based compound that potently suppresses hypoxia-induced HIF-1α transcription (IC50 = 14 nM in HRE-Luc HeLa cells) and VEGF-expression. Shown to effectively induce growth arrest in several cancer cells (IC50 = 2.1, 3.7 & 1.8 µM for HCT116, HepG2 & HeLa cells), although with reduced efficiency in PC3 (IC50 = 25.4 µM). Does neither affect HIF-1α protein accumulation nor HIF-1α/HIF-1β heterodimer complex formation. Suggested to act via impairing HIF-1α/HIF-1β heterodimer-induced transcriptional pathway.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number538254
          Brand Family Calbiochem®
          SynonymsN -(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine, HIF-1 Inhibitor II
          DescriptionGN44028
          References
          ReferencesMinegishi, H., et al. 2013. ACS Med. Chem. Lett. 4, 297.
          Product Information
          FormBrown solid
          Hill FormulaC₁₈H₁₅N₃O₂
          Chemical formulaC₁₈H₁₅N₃O₂
          ReversibleY
          Applications
          Biological Information
          Primary TargetHIF-1α
          Primary Target IC<sub>50</sub>14 nM in HRE-Luc HeLa cells
          Secondary targetVEGF
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          GN44028 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Minegishi, H., et al. 2013. ACS Med. Chem. Lett. 4, 297.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-September-2016 JSW
          SynonymsN -(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine, HIF-1 Inhibitor II
          DescriptionA cell-permeable indenopyrazole based compound that potently suppresses hypoxia-induced HIF-1α transcription (IC50 = 14 nM in HRE-Luc HeLa cells) and VEGF-expression. Shown to effectively induce growth arrest in several cancer cells (IC50 = 2.1, 3.7 & 1.8 µM for HCT116, HepG2 & HeLa cells), although with reduced efficiency in PC3 (IC50 = 25.4 µM). Does neither affect HIF-1α protein accumulation nor HIF-1α/HIF-1β heterodimer complex formation. Suggested to act via impairing HIF-1α/HIF-1β heterodimer-induced transcriptional pathway.
          FormBrown solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₈H₁₅N₃O₂
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMinegishi, H., et al. 2013. ACS Med. Chem. Lett. 4, 297.