345763 GDF-9, Mouse, Recombinant

345763
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥95% by SDS-PAGE

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345763-10UG
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      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 10 μg
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          Description
          OverviewRecombinant, mouse growth differentiation factor 9 (GDF-9) consisting of amino acids 307-477 and expressed in Chinese Hamster Ovary cells. GDF-9 is an oocyte secreted paracrine factor, necessary for mammalian ovarian folliculogenesis. Mature mouse GDF-9 is 90% identical to the amino acid sequence of mature human GDF-9. GDF-9 as a paracrine factor is useful in granulosa cell proliferation and differentiation regulation.
          Catalogue Number345763
          Brand Family Calbiochem®
          References
          ReferencesMottershead, D.G., et al. 2008. Mol. Cell. Endocrinol. 283, 58.
          Gilchrist, R.B., et al. 2006. J. Cell. Sci. 119, 3811.
          Mazerbourg, S., et al. 2004. Mol. Endocrinol. 18, 653.
          Kaivo-Oja, N., et al. 2003. J. Clin. Endocrinol. Metab. 88, 755.
          Roh, J.S., et al. 2003. Endocrinology 144, 172.
          Vitt, U.A., et al. 2002. Biol. Reprod. 67, 473.
          Dong, J., et al. 1996. Nature 383, 531.
          McGrath, S.A., et al. 1995. Mol. Endocrinol. 9, 131.
          McPherron, A.C. and S.J. Lee. 1992. J. Biol. Chem. 268, 3444.
          Product Information
          FormSolid
          FormulationLyophilized from 0.2 µm sterile-filtered HCl, BSA.
          Applications
          ApplicationGDF-9, Mouse, Recombinant, consists of amino acids 307-477 and is expressed in Chinese Hamster Ovary cells. An oocyte secreted paracrine factor that is necessary for mammalian folliculogenesis.
          Biological Information
          Biological activityEffective concentration = 100 ng/ml as measured by induction of Smad2 phosphorylation in P19 mouse embryonal carcinoma cells.
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: <1.0 EU/µg protein
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345763

          References

          Reference overview
          Mottershead, D.G., et al. 2008. Mol. Cell. Endocrinol. 283, 58.
          Gilchrist, R.B., et al. 2006. J. Cell. Sci. 119, 3811.
          Mazerbourg, S., et al. 2004. Mol. Endocrinol. 18, 653.
          Kaivo-Oja, N., et al. 2003. J. Clin. Endocrinol. Metab. 88, 755.
          Roh, J.S., et al. 2003. Endocrinology 144, 172.
          Vitt, U.A., et al. 2002. Biol. Reprod. 67, 473.
          Dong, J., et al. 1996. Nature 383, 531.
          McGrath, S.A., et al. 1995. Mol. Endocrinol. 9, 131.
          McPherron, A.C. and S.J. Lee. 1992. J. Biol. Chem. 268, 3444.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-Sepmtember-2011 RFH
          DescriptionRecombinant, mouse growth differentiation factor 9 (GDF-9) consisting of amino acids 307-477 and expressed in Chinese Hamster Ovary cells. GDF-9 is an oocyte secreted paracrine factor, necessary for mammalian ovarian folliculogenesis. Mature mouse GDF-9 is 90% identical to the amino acid sequence of mature human GDF-9. GDF-9 as a paracrine factor is useful in granulosa cell proliferation and differentiation regulation.
          FormSolid
          FormulationLyophilized from 0.2 µm sterile-filtered HCl, BSA.
          Purity≥95% by SDS-PAGE
          ContaminantsEndotoxin: <1.0 EU/µg protein
          Biological activityEffective concentration = 100 ng/ml as measured by induction of Smad2 phosphorylation in P19 mouse embryonal carcinoma cells.
          SolubilityReconstitute to 100 µg/ml in 4 mM HCl containing 0.1% bovine serum albumin.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMottershead, D.G., et al. 2008. Mol. Cell. Endocrinol. 283, 58.
          Gilchrist, R.B., et al. 2006. J. Cell. Sci. 119, 3811.
          Mazerbourg, S., et al. 2004. Mol. Endocrinol. 18, 653.
          Kaivo-Oja, N., et al. 2003. J. Clin. Endocrinol. Metab. 88, 755.
          Roh, J.S., et al. 2003. Endocrinology 144, 172.
          Vitt, U.A., et al. 2002. Biol. Reprod. 67, 473.
          Dong, J., et al. 1996. Nature 383, 531.
          McGrath, S.A., et al. 1995. Mol. Endocrinol. 9, 131.
          McPherron, A.C. and S.J. Lee. 1992. J. Biol. Chem. 268, 3444.