345749 | GDF-8 Propeptide, His•Tag®, Mouse, Recombinant

345749
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥90% by SDS-PAGE

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      345749-25UG
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      Discontinued
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      Available
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          Glass bottle 25 μg
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          Description
          OverviewRecombinant, mouse growth differentiation factor-8 (GDF-8)/myostatin propeptide, consisting of amino acids 25-285, fused at the C-terminus to a His•Tag® sequence, and expressed in NS0-derived mouse myeloma cells. GDF-8 is a secreted protein that is expressed during embryonic development and in adult skeletal muscle.
          Catalogue Number345749
          Brand Family Calbiochem®
          SynonymsMyostatin Propeptide
          References
          ReferencesHill, J.J. et al. 2003. Molecular Endocrinology 17, 1144.
          Thies, R.S. et al. 2001. Growth Factors 18, 251.
          Chang, H. et al. 2002. Endocrine Reviews 23, 787.
          McPherron, A.C. et al. 1997. Nature 387, 83.
          Product Information
          FormLyophilized
          FormulationLyophilized from 0.2 µm filtered PBS, BSA.
          Applications
          ApplicationGDF-8 Propeptide, His•Tag®, Mouse, Recombinant, consists of amino acids 25-285, fused at the C-terminus to a His•Tag® sequence, and expressed in NS0-derived mouse myeloma cells.
          Biological Information
          Biological activityED₅₀ = 0.05-0.25 µg/ml (using 40 ng/ml rmGDF-8) as measured by inhibition of rmGDF-8 activity in K562 human chronic myelogenous leukemia cells. Approximately 1 µg/ml will completely inhibit GDF-8 activity in K562 cells.
          Purity≥90% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤1.0 EU/µg protein
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstituyion refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          345749

          References

          Reference overview
          Hill, J.J. et al. 2003. Molecular Endocrinology 17, 1144.
          Thies, R.S. et al. 2001. Growth Factors 18, 251.
          Chang, H. et al. 2002. Endocrine Reviews 23, 787.
          McPherron, A.C. et al. 1997. Nature 387, 83.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-June-2011 RFH
          SynonymsMyostatin Propeptide
          DescriptionRecombinant, mouse growth differentiation factor-8 (GDF-8)/myostatin propeptide, consisting of amino acids 25-285, fused at the C-terminus to a His•Tag® sequence, and expressed in NS0-derived mouse myeloma cells. GDF-8 is a secreted protein that is expressed during embryonic development and in adult skeletal muscle.
          FormLyophilized
          FormulationLyophilized from 0.2 µm filtered PBS, BSA.
          Purity≥90% by SDS-PAGE
          ContaminantsEndotoxin: ≤1.0 EU/µg protein
          Biological activityED₅₀ = 0.05-0.25 µg/ml (using 40 ng/ml rmGDF-8) as measured by inhibition of rmGDF-8 activity in K562 human chronic myelogenous leukemia cells. Approximately 1 µg/ml will completely inhibit GDF-8 activity in K562 cells.
          SolubilityReconstitute to 50 µg/ml with sterile PBS containing ≥1% human or bovine serum albumin.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstituyion refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHill, J.J. et al. 2003. Molecular Endocrinology 17, 1144.
          Thies, R.S. et al. 2001. Growth Factors 18, 251.
          Chang, H. et al. 2002. Endocrine Reviews 23, 787.
          McPherron, A.C. et al. 1997. Nature 387, 83.