344931 | Furin Inhibitor II - Calbiochem

344931
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₆H₇₅N₂₅O₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344931-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (Ki = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (Ki = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.
          Catalogue Number344931
          Brand Family Calbiochem®
          SynonymsHexa-D-arginine, H-(D)RRRRRR-NH₂
          References
          ReferencesCameron, A., et al. 2000. J. Biol. Chem. 275, 36741.
          Product Information
          ATP CompetitiveY
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₃₆H₇₅N₂₅O₆
          Chemical formulaC₃₆H₇₅N₂₅O₆
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary Targetfurin
          Primary Target K<sub>i</sub>106 nM against Furin
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344931

          References

          Reference overview
          Cameron, A., et al. 2000. J. Biol. Chem. 275, 36741.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2008 RFH
          SynonymsHexa-D-arginine, H-(D)RRRRRR-NH₂
          DescriptionA polyarginine that acts as a potent, specific, and competitive inhibitor of furin (Ki = 106 nM). Inhibits subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (Ki = 580 nM and 13 µM, respectively). Does not affect the activity of PC2. The D-peptides are suggested to be more resistant to in vivo hydrolysis than the L-peptides.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₆H₇₅N₂₅O₆
          Peptide SequenceH-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂
          Purity≥95% by HPLC
          SolubilityDMSO or H₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesCameron, A., et al. 2000. J. Biol. Chem. 275, 36741.