344580 FtsZ Polymer Stabilizer, PC190723 - Calbiochem

344580
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₈ClF₂N₃O₂S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344580-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 mg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC50 = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.
          Catalogue Number344580
          Brand Family Calbiochem®
          Synonyms3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer
          References
          ReferencesElsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342.
          Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239.
          Haydon, D. J., et al. 2008. Science, 321, 1673.
          Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.
          Product Information
          FormTan powder
          Hill FormulaC₁₄H₈ClF₂N₃O₂S
          Chemical formulaC₁₄H₈ClF₂N₃O₂S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetFtsZ
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344580

          References

          Reference overview
          Elsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342.
          Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239.
          Haydon, D. J., et al. 2008. Science, 321, 1673.
          Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2013 JSW
          Synonyms3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer
          DescriptionA benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 mg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC50 = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubuin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.
          FormTan powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄H₈ClF₂N₃O₂S
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesElsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342.
          Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239.
          Haydon, D. J., et al. 2008. Science, 321, 1673.
          Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.