344280 | Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem

344280
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₆O₉PNa 87860-39-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344280-10UG
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          Plastic ampoule 10 μg
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          Description
          OverviewAn antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC50 = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC50 = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.
          Catalogue Number344280
          Brand Family Calbiochem®
          SynonymsFST, Phosphotrienin
          References
          ReferencesCheng, A., et al. 1998. Cancer Res. 58, 3611.
          Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
          Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.
          Product Information
          CAS number87860-39-7
          ATP CompetitiveN
          FormColorless solid
          Hill FormulaC₁₉H₂₆O₉PNa
          Chemical formulaC₁₉H₂₆O₉PNa
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPP2a
          Primary Target IC<sub>50</sub>3.2 nM, 131 µM, against protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1), respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUQ0600000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344280

          References

          Reference overview
          Cheng, A., et al. 1998. Cancer Res. 58, 3611.
          Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
          Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.

          Brochure

          Title
          Protein Phosphatases Technical Bulletin

          Citations

          Title
        • Ramesh M. Ray, Sujoy bhattacharya and Leonard R. Johnson. (2005) Protein phosphatase 2A (PP2A) regulates apoptosis in IEC-6 cells. Journal of Biological Chemistry 280, 31091-31100.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-June-2008 RFH
          SynonymsFST, Phosphotrienin
          DescriptionAntitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC50 = 3.2 nM). Also inhibits protein phosphatase 1 (PP1) at higher concentrations (IC50 = 131 µM), but has no effect on protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.
          FormColorless solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number87860-39-7
          RTECSUQ0600000
          Chemical formulaC₁₉H₂₆O₉PNa
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityEthanol (10 mg/ml), Methanol (10 mg/ml), or H₂O (50 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesCheng, A., et al. 1998. Cancer Res. 58, 3611.
          Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
          Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.
          Citation
        • Ramesh M. Ray, Sujoy bhattacharya and Leonard R. Johnson. (2005) Protein phosphatase 2A (PP2A) regulates apoptosis in IEC-6 cells. Journal of Biological Chemistry 280, 31091-31100.