344216 | Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem

344216
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344216-5MG
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      Stocked 
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          Plastic ampoule 5 mg
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          Description
          OverviewA potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
          Catalogue Number344216
          Brand Family Calbiochem®
          SynonymsFPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH₂
          References
          ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
          Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
          Le, Y., et al. 1999. J. Immunol. 163, 6777.
          Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
          Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₄₁H₆₁N₉O₇S₂
          Chemical formulaC₄₁H₆₁N₉O₇S₂
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetFormyl Peptide Receptor-Like 1
          Primary Target IC<sub>50</sub>EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344216

          References

          Reference overview
          Bae, Y.S., et al. 2004. J. Immunol. 173, 607.
          Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
          Le, Y., et al. 1999. J. Immunol. 163, 6777.
          Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
          Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-June-2008 RFH
          SynonymsFPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH₂
          DescriptionA potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). More poteut than fmlp at inducing neutrophil chemotaxis, neutrophil complement receptor 3. Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM) and in U937 and HL60 cells. Has no effect inositide phosphate synthecs in a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Radioiodinatable at the tyrosine residue.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₁H₆₁N₉O₇S₂
          Peptide SequenceH-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
          Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
          Le, Y., et al. 1999. J. Immunol. 163, 6777.
          Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
          Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.