343290 | Fluoxetine, Hydrochloride - CAS 56296-78-7 - Calbiochem

343290
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₈F₃NO • HCL 56296-78-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      343290-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T-cells by increasing the Ca2+ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Shown to trigger oxidative stress-induced apoptotic cell death. Also reported to initiate signaling pathways in neuronal cells leading to activation of ERK and NF-κB.
          Catalogue Number343290
          Brand Family Calbiochem®
          Synonymsdl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
          References
          ReferencesBartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507.
          Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159.
          Zhang, A., et al. 2002. J. Med. Chem. 45, 1930.
          Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182.
          Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.
          Product Information
          CAS number56296-78-7
          ATP CompetitiveN
          FormSolid
          Hill FormulaC₁₇H₁₈F₃NO • HCL
          Chemical formulaC₁₇H₁₈F₃NO • HCL
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetSelective serotonin re-uptake inhibitor
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          343290

          References

          Reference overview
          Bartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507.
          Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159.
          Zhang, A., et al. 2002. J. Med. Chem. 45, 1930.
          Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182.
          Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-July-2017 JSW
          Synonymsdl-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
          DescriptionA cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T cells by increasing the Ca2+ influx thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Inhibits leak K+ currents in a reversible and voltage-independent manner (IC50 = 780 nM). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Triggers oxidative stress-induced apoptotic cell death and initiates signaling pathways in neuronal cells leading to an activation of ERK and NF-κB.
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number56296-78-7
          Chemical formulaC₁₇H₁₈F₃NO • HCL
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (5 mg/ml) or Methanol (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 4185
          ReferencesBartholoma, P., et al. 2002. Biochem. Pharmacol. 63, 1507.
          Bian, J.T., et al. 2002. Eur. J. Pharmacol. 453, 159.
          Zhang, A., et al. 2002. J. Med. Chem. 45, 1930.
          Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 3182.
          Edgar, V.A., et al. 1999. Eur. J. Pharmacol. 372, 65.