344150 FPT Inhibitor I - Calbiochem

344150
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₉H₂₉NO₆P · 3Na

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      344150-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewPotent and highly selective inhibitor of farnesyltransferase (FTase; IC50 = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively).
          Catalogue Number344150
          Brand Family Calbiochem®
          Synonyms(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
          References
          ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
          Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₉H₂₉NO₆P · 3Na
          Chemical formulaC₁₉H₂₉NO₆P · 3Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetFarnesyltransferase (Ftase)
          Primary Target IC<sub>50</sub>83 nM against Ftase
          Purity≥85% by NMR
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          344150

          References

          Reference overview
          Manne, V., et al. 1995. Drug Development Res. 34, 121.
          Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-December-2008 JSW
          Synonyms(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
          DescriptionA highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 83 nM). Inhibits geranylgeranyltransferase I (IC50 = 26 µM) and II (IC50 = 47 µM) at much higher concentrations.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₉H₂₉NO₆P · 3Na
          Structure formulaStructure formula
          Purity≥85% by NMR
          SolubilityH₂O (≥10 mg/ml)
          Storage ≤ -70°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
          Toxicity Standard Handling
          ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
          Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.

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          344152 FPT Inhibitor II - Calbiochem Show Pricing & Availability

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors