342500 FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem

342500
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₄H₆₉NO₁₂ 104987-11-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      342500-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewImmunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca2+ release. Inhibits the Ca2+-dependent phosphatase, Protein Phosphatase 2B (Calcineurin; Cat. No. 539568), as well as Na+,K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
          Catalogue Number342500
          Brand Family Calbiochem®
          SynonymsTacrolimus
          References
          ReferencesAsano, K., et al. 1996. In Vivo 10, 537.
          McCall, E., et al. 1996. Circ. Res. 79, 1110.
          Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877.
          Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.
          Product Information
          CAS number104987-11-3
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₄₄H₆₉NO₁₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetImmunosuppressant that blocks T cell proliferation
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSKD4200000
          Safety Information
          R PhraseR: 25

          Toxic if swallowed.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          342500

          References

          Reference overview
          Asano, K., et al. 1996. In Vivo 10, 537.
          McCall, E., et al. 1996. Circ. Res. 79, 1110.
          Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877.
          Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-April-2009 JSW
          SynonymsTacrolimus
          DescriptionImmunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 Binding Protein, thereby reversing its effects on sarcoplamic reticulum Ca2+ release. Shown to inhibit the Ca2+-dependent phosphatase, Calcineurin (Cat. No. 539565), as well as Na+-K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
          FormOff-white solid
          CAS number104987-11-3
          RTECSKD4200000
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesAsano, K., et al. 1996. In Vivo 10, 537.
          McCall, E., et al. 1996. Circ. Res. 79, 1110.
          Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877.
          Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.