341608 | FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem

341608
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₄N₆O₃ 192705-79-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341608-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC50 = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC50 > 50 µM).
          Catalogue Number341608
          Brand Family Calbiochem®
          Synonyms1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD 166866
          References
          ReferencesPanek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
          Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
          Product Information
          CAS number192705-79-6
          FormOff-white solid
          Hill FormulaC₂₀H₂₄N₆O₃
          Chemical formulaC₂₀H₂₄N₆O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341608

          References

          Reference overview
          Panek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
          Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-April-2011 RFH
          Synonyms1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD 166866
          DescriptionA cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC50 = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC50 > 50 µM).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number192705-79-6
          Chemical formulaC₂₀H₂₄N₆O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesPanek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
          Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.