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|341253-5MG||Glass bottle||5 mg||
|Overview||A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8 nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100 µM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2 mg/kg vs. 40 mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1 mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available (Cat. No. 341249).|
|Synonyms||Cyclohexylcarbamic acid-carbamoylhydroxybiphenyl–3–yl)ester, Cyclohexylcarbamic acid-(3ʹ–carbamoyl–6–hydroxybiphenyl–3–yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937|
|References||Clapper, J.R., et al. 2010. Nat. Neurosci. 13, 1265.|
|Structure formula Image|
|Purity||≥95% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
|Clapper, J.R., et al. 2010. Nat. Neurosci. 13, 1265.|
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