341208 | Exoenzyme C3, Clostridium botulinum

341208
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341208-25UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 25 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          341208-50UG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service

              Plastic ampoule 50 μg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              Description
              OverviewCatalyzes the hydrolysis of NAD and, in the presence of Rho, catalyzes the ADP-ribosylation of Asn41 in Rho. Inhibits the progression of the cell cycle from G1 to S phase.
              Catalogue Number341208
              Brand Family Calbiochem®
              References
              ReferencesUdagawa, T., and McIntyre, B.W. 1996. J. Biol. Chem. 271, 12542.
              Yamamoto, M., et al. 1994. J. Dermatol. Sci. 8, 103.
              Yamamoto, M., et al. 1993. Oncogene 8, 1449.
              Popoff, A., et al. 1991. Infect. Immun. 59, 3673.
              Morii, N., et al. 1988. J. Biol. Chem. 263, 12420.
              Hartree, E.F. 1972. Anal. Biochem. 48, 422.
              Weber, K., and Osborn, M. 1969. J. Biol. Chem. 244, 4406.
              Product Information
              CAS number58319-92-9
              FormSolid
              FormulationLyophilized from 20 mM Tris, 50 mM NaCl, 0.5% sucrose, 0.1% dextran, pH 7.5
              Applications
              Biological Information
              Purity≥90% by SDS-PAGE
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 37

              Irritating to respiratory system.
              S PhraseS: 36

              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Irritant
              Storage +2°C to +8°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 months at -70°C.
              Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              341208

              References

              Reference overview
              Udagawa, T., and McIntyre, B.W. 1996. J. Biol. Chem. 271, 12542.
              Yamamoto, M., et al. 1994. J. Dermatol. Sci. 8, 103.
              Yamamoto, M., et al. 1993. Oncogene 8, 1449.
              Popoff, A., et al. 1991. Infect. Immun. 59, 3673.
              Morii, N., et al. 1988. J. Biol. Chem. 263, 12420.
              Hartree, E.F. 1972. Anal. Biochem. 48, 422.
              Weber, K., and Osborn, M. 1969. J. Biol. Chem. 244, 4406.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision08-June-2016 RB
              DescriptionCatalyzes the hydrolysis of NAD. Can be used as a reagent for the detection of Rho proteins. Predominantly catalyzes the ADP ribosylation of the Asn41 amino acid residue in Rho. Treatment of cultured cells with exoenzyme C3 has been shown to induce ADP-ribosylation of RhoA protein and to reduce cell growth rate and saturation density. Its growth inhibitory effects appear to result from blockage at the G1 to S phase transition, causing the accumulation of cells in the G1 phase.
              FormSolid
              FormulationLyophilized from 20 mM Tris, 50 mM NaCl, 0.5% sucrose, 0.1% dextran, pH 7.5
              CAS number58319-92-9
              Purity≥90% by SDS-PAGE
              SolubilityReconstitute with sterile distilled H₂O
              Storage +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 months at -70°C.
              Toxicity Irritant
              ReferencesUdagawa, T., and McIntyre, B.W. 1996. J. Biol. Chem. 271, 12542.
              Yamamoto, M., et al. 1994. J. Dermatol. Sci. 8, 103.
              Yamamoto, M., et al. 1993. Oncogene 8, 1449.
              Popoff, A., et al. 1991. Infect. Immun. 59, 3673.
              Morii, N., et al. 1988. J. Biol. Chem. 263, 12420.
              Hartree, E.F. 1972. Anal. Biochem. 48, 422.
              Weber, K., and Osborn, M. 1969. J. Biol. Chem. 244, 4406.