325001 Epothilone B, Synthetic

325001
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₄₁NO₆S 152044-54-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      325001-1MG
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      Stocked 
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      Available
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          Plastic ampoule 1 mg
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          Description
          OverviewA structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).
          Catalogue Number325001
          Brand Family Calbiochem®
          SynonymsEpoB
          References
          ReferencesGiannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
          Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
          Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
          Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
          Nicolaou, K.C., et al. 1997. Nature 387, 268.
          Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.
          Product Information
          CAS number152044-54-7
          ATP CompetitiveN
          DeclarationNot available for sale in Germany.
          FormWhite to off-white solid
          Hill FormulaC₂₇H₄₁NO₆S
          Chemical formulaC₂₇H₄₁NO₆S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetP-glycoprotein-expressing multidrug resistant (MDR) cells
          Primary Target IC<sub>50</sub>2 nM for MDR CCRF-CEM/VBL100 cells
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 23/24/25-37/38-41-46-60

          Toxic by inhalation, in contact with skin and if swallowed.
          Irritating to respiratory system and skin.
          Risk of serious damage to eyes.
          May cause heritable genetic damage.
          May impair fertility.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          325001

          References

          Reference overview
          Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
          Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
          Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
          Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
          Nicolaou, K.C., et al. 1997. Nature 387, 268.
          Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-June-2008 RFH
          SynonymsEpoB
          DescriptionA structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multi drug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number152044-54-7
          Chemical formulaC₂₇H₄₁NO₆S
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
          Toxicity Toxic & Carcinogenic / Teratogenic
          ReferencesGiannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
          Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
          Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
          Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
          Nicolaou, K.C., et al. 1997. Nature 387, 268.
          Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.