324760 Endothall - CAS 145-73-3 - Calbiochem

324760
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₀O₅ 145-73-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324760-20MG
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          Alu drum 20 mg
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          Description
          OverviewA cell-permeable, specific inhibitor of protein phosphatase 2A (PP2A, IC50 = 90 nM). Exhibits only a weak effect on PP1 (IC50 = 5 µM). Causes dose- and time-dependent cytostasis at the G2/M phase in hepatocellular carcinoma cell lines.
          Catalogue Number324760
          Brand Family Calbiochem®
          Synonyms7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid
          References
          ReferencesAyaydin, F., et al. 2000. Plant J. 23, 85.
          Thiery, J.P., et al. 1999. Hepatology 29, 1406.
          Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435.
          Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.
          Product Information
          CAS number145-73-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₈H₁₀O₅
          Chemical formulaC₈H₁₀O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPP2A
          Primary Target IC<sub>50</sub>90 nM against protein phosphatase 2A (PP2A)
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRN7875000
          Safety Information
          R PhraseR: 21-25-36/37/38

          Harmful in contact with skin.
          Toxic if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324760

          References

          Reference overview
          Ayaydin, F., et al. 2000. Plant J. 23, 85.
          Thiery, J.P., et al. 1999. Hepatology 29, 1406.
          Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435.
          Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.

          Brochure

          Title
          Protein Phosphatases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-June-2008 RFH
          Synonyms7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid
          DescriptionA specific, cell-permeable inhibitor of protein phosphatase 2A (PP2A)(IC50 = 90 nM). Exhibits only weak inhibitory activity towards protein phosphatase 1 (PP1) (IC50 = 5 µM). Causes dose- and time-dependent cytostasis at the G2/M phase in hepatocellular carcinoma cell lines.
          FormWhite solid
          CAS number145-73-3
          RTECSRN7875000
          Chemical formulaC₈H₁₀O₅
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityH₂O (25 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesAyaydin, F., et al. 2000. Plant J. 23, 85.
          Thiery, J.P., et al. 1999. Hepatology 29, 1406.
          Li, Y.M., et al. 1993. Biochem. Pharmacol. 46, 1435.
          Li, Y.M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA 89, 11867.