324683 | Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem

324683
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₆O₈ · 2H₂O 476-66-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324683-500MG
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          Glass bottle 500 mg
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          Description
          OverviewA cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
          Catalogue Number324683
          Brand Family Calbiochem®
          Synonyms4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II
          References
          ReferencesSelvi, B.R., et al. 2009, J. Biol. Chem. In press.
          Cozza, G., et al. 2006. J. Med. Chem. 49, 2363.
          Wang, B.H., et al. 1998. Planta Med. 64, 195.
          Constantinou, A., et al. 1995. Nutr. Cancer 23, 121.
          Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.
          Product Information
          CAS number476-66-4
          ATP CompetitiveY
          FormSlightly Beige Powder
          Hill FormulaC₁₄H₆O₈ · 2H₂O
          Chemical formulaC₁₄H₆O₈ · 2H₂O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCDK2
          Primary Target IC<sub>50</sub>40 nM against CK2; 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, against DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR, respectively
          Purity≥98% by HPCE
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDJ2620000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324683

          References

          Reference overview
          Selvi, B.R., et al. 2009, J. Biol. Chem. In press.
          Cozza, G., et al. 2006. J. Med. Chem. 49, 2363.
          Wang, B.H., et al. 1998. Planta Med. 64, 195.
          Constantinou, A., et al. 1995. Nutr. Cancer 23, 121.
          Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2011 JSW
          Synonyms4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II
          DescriptionA cell-permeable, reversible, and potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
          FormSlightly Beige Powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number476-66-4
          RTECSDJ2620000
          Chemical formulaC₁₄H₆O₈ · 2H₂O
          Structure formulaStructure formula
          Purity≥98% by HPCE
          Solubility1 M NaOH (10 mg/ml) or Ethanol (10 mg/ml). For complete solubilization in ethanol, slight heating may be required.
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.
          Toxicity Irritant
          Merck USA index14, 3547
          ReferencesSelvi, B.R., et al. 2009, J. Biol. Chem. In press.
          Cozza, G., et al. 2006. J. Med. Chem. 49, 2363.
          Wang, B.H., et al. 1998. Planta Med. 64, 195.
          Constantinou, A., et al. 1995. Nutr. Cancer 23, 121.
          Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.

          Related Products & Applications

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Casein Kinase (CK) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Topoisomerase Related Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors