324483 Ebselen - CAS 60940-34-3 - Calbiochem

324483
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₉NOSe 60940-34-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324483-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable, non-selective inhibitor of COX-1 and COX-2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent active against acute focal ischemic injury. Inhibits LPS-induced NF-κB nuclear translocation and LPS-induced phosphorylation of JNK.
          Catalogue Number324483
          Brand Family Calbiochem®
          Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
          References
          ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
          Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
          Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
          Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
          Wang, J.F., et al. 1992. Hepatology 5, 112.
          Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
          Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
          Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.
          Product Information
          CAS number60940-34-3
          ATP CompetitiveN
          FormLyophilized solid
          Hill FormulaC₁₃H₉NOSe
          Chemical formulaC₁₃H₉NOSe
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCOX-1, COX-2
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324483

          References

          Reference overview
          Shimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
          Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
          Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
          Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
          Wang, J.F., et al. 1992. Hepatology 5, 112.
          Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
          Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
          Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-June-2008 RFH
          Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
          DescriptionNon-selective, cell-permeable, inhibitor of the cyclooxygenase activity of prostaglandin H synthase 1 and 2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent against acute focal ischemic injury.
          FormLyophilized solid
          CAS number60940-34-3
          Chemical formulaC₁₃H₉NOSe
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (5 mg/ml) or Ethanol
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
          Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
          Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
          Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
          Wang, J.F., et al. 1992. Hepatology 5, 112.
          Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
          Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
          Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.