341209 EUK-8 - Calbiochem

341209
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₁₄ClMnN₂O₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      341209-10MG
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      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Contact Customer Service
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          Plastic ampoule 10 mg
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          Description
          OverviewA synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation. Imparts protection against Aβ40 and Aβ42 toxicity in hippocampal cultures.
          Catalogue Number341209
          Brand Family Calbiochem®
          References
          ReferencesColparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359.
          Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
          Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
          Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
          Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
          Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.
          Product Information
          ATP CompetitiveN
          DeclarationNot available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States.
          FormDark brown solid
          Hill FormulaC₁₆H₁₄ClMnN₂O₂
          Chemical formulaC₁₆H₁₄ClMnN₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetSuperoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities
          Purity≥90% by elemental analysis
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          341209

          References

          Reference overview
          Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359.
          Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
          Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
          Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
          Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
          Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2008 RFH
          DescriptionA synthetic salen-manganese complex with high superoxide dismutase (SOD), catalase, and oxyradical scavenger activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation and imparts protection against Aβ40 and Aβ42 toxicity in hippocampal cultures.
          FormDark brown solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₆H₁₄ClMnN₂O₂
          Structure formulaStructure formula
          Purity≥90% by elemental analysis
          SolubilityDMSO (20 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
          Toxicity Standard Handling
          ReferencesColparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol. 130, 359.
          Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
          Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
          Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
          Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
          Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.