330005 | EST - CAS 88321-09-9 - Calbiochem

330005
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₃₀N₂O₅ 88321-09-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      330005-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but devoid of charged groups. Reported to inhibit calpain-1 activation. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy.
          Catalogue Number330005
          Brand Family Calbiochem®
          SynonymsLoxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d
          References
          ReferencesInomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129.
          Mehdi, S. 1991. Trends Biochem. Sci. 16, 150.
          McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun. 158, 432.
          Tamai, M., et al. 1987. J. Pharmacobiodyn. 10, 678.
          Komatsu, K., et al. 1986. Exp. Neurol. 91, 23.
          Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672.
          Product Information
          CAS number88321-09-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₇H₃₀N₂O₅
          Chemical formulaC₁₇H₃₀N₂O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcalpain-1
          Primary Target IC<sub>50</sub>10-100 µM for calpain-1
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRR0404300
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          330005

          References

          Reference overview
          Inomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129.
          Mehdi, S. 1991. Trends Biochem. Sci. 16, 150.
          McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun. 158, 432.
          Tamai, M., et al. 1987. J. Pharmacobiodyn. 10, 678.
          Komatsu, K., et al. 1986. Exp. Neurol. 91, 23.
          Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure

          Citations

          Title
        • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-July-2013 JSW
          SynonymsLoxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d
          DescriptionA cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but is devoid of charged groups. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy. Recommended working concentration is 10-100 µM.
          FormWhite solid
          CAS number88321-09-9
          RTECSRR0404300
          Chemical formulaC₁₇H₃₀N₂O₅
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
          Toxicity Irritant
          ReferencesInomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129.
          Mehdi, S. 1991. Trends Biochem. Sci. 16, 150.
          McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun. 158, 432.
          Tamai, M., et al. 1987. J. Pharmacobiodyn. 10, 678.
          Komatsu, K., et al. 1986. Exp. Neurol. 91, 23.
          Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672.
          Citation
        • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.