328008 | ERK Inhibitor II, Negative Control, FR180209 - CAS 1177970-73-8 - Calbiochem

328008
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₂N₆O 1177970-73-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      328008-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable Erk Inhibitor II (Cat. No. 328007) structural analog that acts as a isoform-selective Aurora B kinase inhibitor (95% inhibition at 1 µM; [ATP] = 10 µM) with little or no activity against Aurora A or C (0% and 16% inhibition, respectively, at 1 µM; [ATP] = 15 µM), Also shown to inhibit Chk2, IRR/INSRR, and Ack1/TNK2 (% inhibition/[ATP] = 81%/70 µM, 75%/200 µM, and 71%/70 µM, respectively), while exhibiting much reduced or no inhibitory potency toward a panel of 228 other kinases, including Erk1/2.
          Catalogue Number328008
          Brand Family Calbiochem®
          Synonyms5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ol, Chk2 Inhibitor IV, Aurora Kinase Inhibitor XII, Irfin1, Insulin Receptor Family Inhibitor
          References
          ReferencesAnastassiadis, T., et al. 2013. J. Biol. Chem. 288, In press.
          Gao, Y., et al. 2013. Biochem. J. in press.
          Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
          Product Information
          CAS number1177970-73-8
          ATP CompetitiveN
          FormGreen solid
          Hill FormulaC₁₈H₁₂N₆O
          Chemical formulaC₁₈H₁₂N₆O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetAurora B kinase
          Primary Target IC<sub>50</sub>95% inhibition at 10 µM using 1 µM; [ATP]
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          328008

          References

          Reference overview
          Anastassiadis, T., et al. 2013. J. Biol. Chem. 288, In press.
          Gao, Y., et al. 2013. Biochem. J. in press.
          Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-March-2013 JSW
          Synonyms5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ol, Chk2 Inhibitor IV, Aurora Kinase Inhibitor XII, Irfin1, Insulin Receptor Family Inhibitor
          DescriptionA cell-permeable Erk Inhibitor II (Cat. No. 328007) structural analog that acts as a isoform-selective Aurora B kinase inhibitor (95% inhibition at 1 µM; [ATP] = 10 µM) with little or no activity against Aurora A or C (0% and 16% inhibition, respectively, at 1 µM; [ATP] = 15 µM), Also shown to inhibit Chk2, IRR/INSRR, and Ack1/TNK2 (% inhibition/[ATP] = 81%/70 µM, 75%/200 µM, and 71%/70 µM, respectively), while exhibiting much reduced or no inhibitory potency toward a panel of 228 other kinases, including Erk1/2.
          FormGreen solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1177970-73-8
          Chemical formulaC₁₈H₁₂N₆O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAnastassiadis, T., et al. 2013. J. Biol. Chem. 288, In press.
          Gao, Y., et al. 2013. Biochem. J. in press.
          Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.