324840 | EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem

324840
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₁ClFN₅O•2.5H₂O 881001-19-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324840-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable, ATP-binding site-targeting alkynamidopyrimidine compound that acts as a potent and irreversible inhibitor of erbB activities (IC50 = 0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively). Inhibits EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells (IC50 = 2.5 and 24 nM, respectively).
          Catalogue Number324840
          Brand Family Calbiochem®
          SynonymsN-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)2-butynamide
          References
          ReferencesKlutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475.
          Product Information
          CAS number881001-19-0
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₇H₁₁ClFN₅O•2.5H₂O
          Chemical formulaC₁₇H₁₁ClFN₅O•2.5H₂O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetEGFR/ErbB-2/ErbB-4
          Primary Target IC<sub>50</sub>0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively; 2.5 and 24 nM against EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324840

          References

          Reference overview
          Klutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-May-2010 JSW
          SynonymsN-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)2-butynamide
          DescriptionA cell-permeable, ATP-binding site-targeting alkynamidopyrimidine compound that acts as a potent and irreversible inhibitor of erbB activities (IC50 = 0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively). Inhibits EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells (IC50 = 2.5 and 24 nM, respectively).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number881001-19-0
          Chemical formulaC₁₇H₁₁ClFN₅O•2.5H₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (4 mg/ml). Use fresh DMSO only.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKlutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475.