324841 | EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor - CAS 1135256-66-4 - Calbiochem

324841
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₈Cl₂N₆O 1135256-66-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324841-2MG
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          Plastic ampoule 2 mg
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          Description
          OverviewA cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Src, and EGFR (IC50 = 0.15, 0.18, 1.76, and 5.47 µM, respectively), while exhibiting little activity against InsR, PKC, or CDK4/Cyclin D1 (IC50 >50 µM). The inhibition is shown to be ATP-competitive in the case of FGFR-1, PDGFR-β, and EGFR, but noncompetitive in the case of c-Src.
          Catalogue Number324841
          Brand Family Calbiochem®
          Synonyms1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828, PDGFR Tyrosine Kinase Inhibitor XIII
          References
          ReferencesHamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
          Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.
          Product Information
          CAS number1135256-66-4
          FormPale yellow solid
          Hill FormulaC₁₈H₁₈Cl₂N₆O
          Chemical formulaC₁₈H₁₈Cl₂N₆O
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥ 97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-37-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324841

          References

          Reference overview
          Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
          Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-May-2011 RFH
          Synonyms1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828, PDGFR Tyrosine Kinase Inhibitor XIII
          DescriptionA cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Src, and EGFR (IC50 = 0.15, 0.18, 1.76, and 5.47 µM, respectively), while exhibiting little activity against InsR, PKC, or CDK4/Cyclin D1 (IC50 >50 µM). The inhibition is shown to be ATP-competitive in the case of FGFR-1, PDGFR-β, and EGFR, but noncompetitive in the case of c-Src.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1135256-66-4
          Chemical formulaC₁₈H₁₈Cl₂N₆O
          Structure formulaStructure formula
          Purity≥ 97% by HPLC
          SolubilityDMSO (25 mg/ml) or Ethanol (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesHamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
          Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.