324411 Dynamin Inhibitor II, MiTMAB - CAS 1119-97-7 - Calbiochem

324411
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₃₈NBr 1119-97-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324411-500MG
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          Glass bottle 500 mg
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          Description
          OverviewA cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
          Catalogue Number324411
          Brand Family Calbiochem®
          SynonymsTetradecyltrimethylammonium Bromide, Myristyltrimethylammonium Bromide, TTAB
          References
          ReferencesQuan, A., et al. 2007. Mol. Pharmacol. 72, 1425.
          Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.
          Product Information
          CAS number1119-97-7
          FormWhite solid
          Hill FormulaC₁₇H₃₈NBr
          Chemical formulaC₁₇H₃₈NBr
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Purity≥99% by Titration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 34

          Causes burns.
          S PhraseS: 26-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Corrosive
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324411

          References

          Reference overview
          Quan, A., et al. 2007. Mol. Pharmacol. 72, 1425.
          Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-April-2008 JSW
          SynonymsTetradecyltrimethylammonium Bromide, Myristyltrimethylammonium Bromide, TTAB
          DescriptionA cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1119-97-7
          Chemical formulaC₁₇H₃₈NBr
          Purity≥99% by Titration
          SolubilityDMSO (10 mg/ml) or H₂O (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Corrosive
          Merck USA index14, 6336
          ReferencesQuan, A., et al. 2007. Mol. Pharmacol. 72, 1425.
          Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.