324410 | Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

324410
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₄N₂O₄ 304448-55-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      324410-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
          Catalogue Number324410
          Brand Family Calbiochem®
          Synonyms3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
          References
          ReferencesYoung, A., et al. 2009. Biochem. J. , In press.
          Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
          Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
          Macia. E., et al. 2006. Dev. Cell 10, 839.
          Product Information
          CAS number304448-55-3
          FormPale yellow solid
          Hill FormulaC₁₈H₁₄N₂O₄
          Chemical formulaC₁₈H₁₄N₂O₄
          Structure formula ImageStructure formula Image
          Applications
          ApplicationDynamin Inhibitor I, Dynasore, CAS 304448-55-3, is a cell-permeable inhibitor of the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. Has no significant effect on MxA and Cdc42.
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 50

          Very toxic to aquatic organisms.
          S PhraseS: 22-24/25

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Environmental Hazard
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          324410

          References

          Reference overview
          Young, A., et al. 2009. Biochem. J. , In press.
          Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
          Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
          Macia. E., et al. 2006. Dev. Cell 10, 839.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-May-2009 RFH
          Synonyms3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
          DescriptionA cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number304448-55-3
          Chemical formulaC₁₈H₁₄N₂O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (16 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Environmental Hazard
          ReferencesYoung, A., et al. 2009. Biochem. J. , In press.
          Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
          Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
          Macia. E., et al. 2006. Dev. Cell 10, 839.