287895 | Drosophila Antennapedia Homeo-Domain (43-58) - Calbiochem

287895
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₀₄H₁₆₈N₃₄O₂₀S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      287895-1MG
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      Stocked 
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          Plastic ampoule 1 mg
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          Description
          OverviewThe membrane translocation signal sequence from Drosophila Antennapedia homeo-domain (43-58) that is reported to act as an inhibitor of protein kinase G Iα (Ki = 970 nM). Does not exhibit significant inhibition against protein kinase A (PKA) (Ki = 107 µM). May be useful for intracellular delivery of highly charged peptides by covalent attachment.
          Catalogue Number287895
          Brand Family Calbiochem®
          SynonymsDT-5, RQIKIWFQNRRMKWKK, PKG Inhibitor V
          References
          ReferencesDostman, W.R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
          Derossi, D., et al. 1998. Trends Cell Biol. 8, 84.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₀₄H₁₆₈N₃₄O₂₀S
          Chemical formulaC₁₀₄H₁₆₈N₃₄O₂₀S
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetPKG1α
          Primary Target K<sub>i</sub>970 nM against protein kinase G Iα
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          287895

          References

          Reference overview
          Dostman, W.R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
          Derossi, D., et al. 1998. Trends Cell Biol. 8, 84.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-June-2008 RFH
          SynonymsDT-5, RQIKIWFQNRRMKWKK, PKG Inhibitor V
          DescriptionThe membrane translocation signal sequence from Drosophila Antennapedia homeo-domain (43-58) that has been shown to inhibit protein kinase G Iα (PKG Iα) (Ki = 970 nM). Does not exhibit significant inhibition against protein kinase A (PKA) (Ki = 107 µM). May also be useful for intracellular delivery of highly charged peptides by covalent attachment.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₀₄H₁₆₈N₃₄O₂₀S
          Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDostman, W.R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
          Derossi, D., et al. 1998. Trends Cell Biol. 8, 84.