287840 Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na

Primary Target: COX-1
287840
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₀Cl₂NO₂ · Na 15307-79-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      287840-1GM
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          		 1 gm
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          Description
          OverviewA cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM).
          Catalogue Number287840
          Brand Family Calbiochem®
          Synonyms2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
          References
          ReferencesKato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
          Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
          Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
          Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
          Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
          Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
          Product Information
          CAS number15307-79-6
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₄H₁₀Cl₂NO₂ · Na
          Chemical formulaC₁₄H₁₀Cl₂NO₂ · Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCOX-1
          Primary Target IC<sub>50</sub>60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSAG6330000
          Safety Information
          R PhraseR: 23/24/25-63

          Toxic by inhalation, in contact with skin and if swallowed.
          Possible risk of harm to the unborn child.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          287840

          References

          Reference overview
          Kato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
          Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
          Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
          Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
          Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
          Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-April-2008 RFH
          Synonyms2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
          DescriptionA potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC50 = 76 nM) and COX-2 (IC50 = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC50 ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.
          FormWhite solid
          CAS number15307-79-6
          RTECSAG6330000
          Chemical formulaC₁₄H₁₀Cl₂NO₂ · Na
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityH₂O (25 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 3081
          ReferencesKato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
          Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
          Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
          Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
          Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
          Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.