265005 Dexamethasone - CAS 50-02-2 - Calbiochem

265005
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₉FO₅ 50-02-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      265005-100MG
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          Plastic ampoule 100 mg
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          Description
          OverviewMost active and highly stable glucocorticoid. Causes a reduction in cyclin A and Cdk2 activity, and inhibition of G1/S transition in osteoblasts. Inhibits the phosphorylation of retinoblastoma (Rb) protein. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+ - K+ pump. Induces apoptosis in human thymocytes.
          Catalogue Number265005
          Brand Family Calbiochem®
          Synonyms9α-Fluoro-16α-methylprednisolone
          References
          ReferencesReil, T.D., et al. 2000. J. Surg. Res. 92, 108.
          Smith, E., et al. 2000. J. Biol. Chem. 275, 1992.
          Petit, P.X., et al. 1995. J. Cell Biol. 130, 157.
          Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
          Donis, J.A., et al. 1993. Biotechniques 15, 786.
          Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
          Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
          Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383.
          Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341.
          Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
          Warters, R.L. 1992. Cancer Res. 52, 883.
          Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490.
          Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
          Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.
          Product Information
          CAS number50-02-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₂H₂₉FO₅
          Chemical formulaC₂₂H₂₉FO₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationDexamethasone, CAS 50-02-2, is one of the most active and highly stable glucocorticoids. Inhibits the expression of inducible, but not constitutive NOS in vascular endothelial cells (IC50 = 5 nM).
          Biological Information
          Primary TargetPhosphorylation of rb protein
          Primary Target IC<sub>50</sub>5 nM Inhibiting the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells
          Purity≥99% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSTU3980000
          Safety Information
          R PhraseR: 36/37/38-43-63

          Irritating to eyes, respiratory system and skin.
          May cause sensitization by skin contact.
          Possible risk of harm to the unborn child.
          S PhraseS: 24-26-36/37

          Avoid contact with skin.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing and gloves.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          265005

          References

          Reference overview
          Reil, T.D., et al. 2000. J. Surg. Res. 92, 108.
          Smith, E., et al. 2000. J. Biol. Chem. 275, 1992.
          Petit, P.X., et al. 1995. J. Cell Biol. 130, 157.
          Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
          Donis, J.A., et al. 1993. Biotechniques 15, 786.
          Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
          Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
          Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383.
          Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341.
          Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
          Warters, R.L. 1992. Cancer Res. 52, 883.
          Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490.
          Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
          Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-November-2008 RFH
          Synonyms9α-Fluoro-16α-methylprednisolone
          DescriptionMost active and highly stable glucocorticoid. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and antirheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6 h incubation at 37°C.
          FormWhite solid
          CAS number50-02-2
          RTECSTU3980000
          Chemical formulaC₂₂H₂₉FO₅
          Structure formulaStructure formula
          Purity≥99% by TLC
          SolubilityDMSO (25 mg/ml), chloroform or Ethanol
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 2943
          ReferencesReil, T.D., et al. 2000. J. Surg. Res. 92, 108.
          Smith, E., et al. 2000. J. Biol. Chem. 275, 1992.
          Petit, P.X., et al. 1995. J. Cell Biol. 130, 157.
          Stern, N., et al. 1994. Am. J. Hypertens. 7, 146.
          Donis, J.A., et al. 1993. Biotechniques 15, 786.
          Ohoka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
          Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
          Vandewalle, A., et al. 1993. J. Cell Physiol. 156, 383.
          Nieto, M.A., et al. 1992. Clin. Exp. Immunol. 88, 341.
          Walsh, D., and Avashia, J. 1992. Cleveland Clin. J. Med. 59, 505.
          Warters, R.L. 1992. Cancer Res. 52, 883.
          Sperber, K., et al. 1991. J. Allergy Clin. Immunol. 87, 490.
          Radomski, M.W., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 10043.
          Bettger, W.J., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 5588.